BDBM306530 (+-)-N-{[6-amino-2-methyl-4- (propan-2-yl)pyridin-3- yl]methyl}-12-(2,4- difluorophenyl)-15-oxatetra- cyclo[6.6.1.02,7.09,14]pentadeca- 2,4,6,9,11,13-hexaene-4- carboxamide::US10144746, Compound 173

SMILES: CC(C)c1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c2c1)c1cc(ccc31)-c1ccc(F)cc1F

InChI Key: InChIKey=JVTVTOMEUVTPTA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306530   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306530 ((+-)-N-{[6-amino-2-methyl-4- (propan-2-yl)pyridin-...) Show SMILES CC(C)c1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c2c1)c1cc(ccc31)-c1ccc(F)cc1F Show InChI InChI=1S/C31H27F2N3O2/c1-15(2)23-13-28(34)36-16(3)26(23)14-35-31(37)18-5-8-22-25(11-18)30-24-10-17(4-7-21(24)29(22)38-30)20-9-6-19(32)12-27(20)33/h4-13,15,29-30H,14H2,1-3H3,(H2,34,36)(H,35,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.02	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair