BDBM306593 (1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-12-(pyrrolidin- 1-yl)-15-oxatetracyclo [6.6.1.02,7.09,14]pentadeca- 2,4,6.9,11,13-hexaene-4- carboxamide::US10144746, Compound 236
SMILES: NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)N4CCCC4)c3c2)cc1
InChI Key: InChIKey=AEPLPJDYVFDMKA-RPBOFIJWSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasma kallikrein (Homo sapiens (Human)) | BDBM306593 ((1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-12-(py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Global Blood Therapeutics, Inc. US Patent | Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w... | US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH | |||||||||||
More data for this Ligand-Target Pair |