BDBM306604 (1R,8S)-N-{[6-amino-2-methyl-4- (oxan-4-yl)pyridin-3- yl]methyl)-12-(2,4- difluorophenyl)-15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca-2,4,6,9,11,13- hexaene-4-carboxamide::US10144746, Compound 247
SMILES: Cc1nc(N)cc(C2CCOCC2)c1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(F)cc1F
InChI Key: InChIKey=SGLCEUPAXRNQPL-AJQTZOPKSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasma kallikrein (Homo sapiens (Human)) | BDBM306604 ((1R,8S)-N-{[6-amino-2-methyl-4- (oxan-4-yl)pyridin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | n/a | n/a |
Global Blood Therapeutics, Inc. US Patent | Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w... | US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH | |||||||||||
More data for this Ligand-Target Pair |