BDBM306643 (1S,8R)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)methyl]- 12-(1H-pyrazol-l-yl)15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca-2,4,6,9,11,13- hexaene-4-carboxamide::US10144746, Compound 286

SMILES: NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-n2cccn2)c(F)c1

InChI Key: InChIKey=GWKRUJSWYBMOMH-RPWUZVMVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306643   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306643 ((1S,8R)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...) Show SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-n2cccn2)c(F)c1 |r| Show InChI InChI=1S/C26H19F2N5O2/c27-21-9-14(25(29)30)10-22(28)20(21)12-31-26(34)13-2-4-16-18(8-13)24-19-11-15(33-7-1-6-32-33)3-5-17(19)23(16)35-24/h1-11,23-24H,12H2,(H3,29,30)(H,31,34)/t23-,24+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.45	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair