BDBM307666 2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridin-2-yl)-6- (pyridin-2- yl)isoindolin-1-one::US10150755, Compound 58

SMILES: O=C1N(Cc2ccc(cc12)-c1ccccn1)c1cccc(n1)-c1nncn1C1CC1

InChI Key: InChIKey=DIYRMJUBPDCHKT-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307666   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM307666 (2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...) Show SMILES O=C1N(Cc2ccc(cc12)-c1ccccn1)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C23H18N6O/c30-23-18-12-15(19-4-1-2-11-24-19)7-8-16(18)13-28(23)21-6-3-5-20(26-21)22-27-25-14-29(22)17-9-10-17/h1-8,11-12,14,17H,9-10,13H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q2125VQ8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM307666 (2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...) Show SMILES O=C1N(Cc2ccc(cc12)-c1ccccn1)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C23H18N6O/c30-23-18-12-15(19-4-1-2-11-24-19)7-8-16(18)13-28(23)21-6-3-5-20(26-21)22-27-25-14-29(22)17-9-10-17/h1-8,11-12,14,17H,9-10,13H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q27P91GS
					More data for this Ligand-Target Pair