BDBM307721 (3R)-N-{5-chloro-4-[1-(3,4-difluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide::US9650358, Example 17

SMILES: Fc1ccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)[C@@H]3CCCNC3)ncc2Cl)cc1F

InChI Key: InChIKey=BIQMZMRTBIRQLB-QGZVFWFLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307721   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM307721 ( (3R)-N-{5-chloro-4-[1-(3,4-difluorobenzyl)-1H-ben...) Show SMILES Fc1ccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)[C@@H]3CCCNC3)ncc2Cl)cc1F Show InChI InChI=1S/C25H22ClF2N5O/c26-19-12-30-24(32-25(34)17-2-1-7-29-11-17)10-18(19)16-4-6-22-23(9-16)33(14-31-22)13-15-3-5-20(27)21(28)8-15/h3-6,8-10,12,14,17,29H,1-2,7,11,13H2,(H,30,32,34)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...				US Patent US9650358 (2017) BindingDB Entry DOI: 10.7270/Q2057J0M
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