BDBM307894 N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-oxo spiro[3.3]heptane-2-carboxamide::US9650358, Example 190
SMILES: Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)C3CC4(C3)CC(=O)C4)ncc2Cl)c1
InChI Key: InChIKey=NRWQRLYYYQQFBT-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent kinase 9 (Homo sapiens (Human)) | BDBM307894 ( N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc. US Patent | Assay Description CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in... | US Patent US9650358 (2017) BindingDB Entry DOI: 10.7270/Q2057J0M | |||||||||||
More data for this Ligand-Target Pair |