BDBM307930 trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(pyridin-3-ylmethyl)cyclohexane-1,4-diamine::US9650358, Example 226

SMILES: Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(N[C@H]3CC[C@@H](CC3)NCc3cccnc3)ncc2Cl)c1

InChI Key: InChIKey=SXPLEPVGURNMBT-DIVCQZSQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307930   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM307930 ( trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzim...) Show SMILES Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(N[C@H]3CC[C@@H](CC3)NCc3cccnc3)ncc2Cl)c1 |r,wU:23.28,wD:20.21,(2.76,10.77,;3.23,9.31,;4.74,8.99,;5.22,7.52,;4.19,6.38,;2.68,6.7,;1.65,5.55,;2.13,4.09,;1.22,2.84,;2.13,1.6,;3.59,2.07,;4.92,1.3,;6.26,2.07,;6.26,3.61,;4.92,4.38,;3.59,3.61,;7.59,4.38,;7.59,5.92,;8.92,6.69,;8.92,8.23,;10.26,9,;11.59,8.23,;12.93,9,;12.93,10.54,;11.59,11.31,;10.26,10.54,;14.26,11.31,;15.59,10.54,;16.93,11.31,;18.26,10.54,;19.59,11.31,;19.59,12.85,;18.26,13.62,;16.93,12.85,;10.26,5.92,;10.26,4.38,;8.92,3.61,;8.92,2.07,;2.2,8.16,)| Show InChI InChI=1S/C31H30ClFN6/c32-28-18-36-31(38-26-9-7-25(8-10-26)35-17-22-4-2-12-34-16-22)15-27(28)23-6-11-29-30(14-23)39(20-37-29)19-21-3-1-5-24(33)13-21/h1-6,11-16,18,20,25-26,35H,7-10,17,19H2,(H,36,38)/t25-,26-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...				US Patent US9650358 (2017) BindingDB Entry DOI: 10.7270/Q2057J0M
					More data for this Ligand-Target Pair