BDBM310301 US10150760, Example 97.0::US10150760, Example 98.0

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCCO1

InChI Key: InChIKey=LYDPDCGSDWPWSW-UCNVEGJOSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 310301   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM310301 (US10150760, Example 97.0 | US10150760, Example 98....) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,wD:18.19,33.35,(-7.42,2.38,;-6.09,1.61,;-4.76,2.38,;-4.76,3.92,;-3.42,4.69,;-2.09,3.92,;-2.09,2.38,;-.75,1.61,;.58,2.38,;-3.42,1.61,;-3.42,.07,;-2.18,-.84,;-.84,-.07,;.49,-.84,;-.28,-2.17,;1.26,-2.17,;1.82,-.07,;1.82,1.47,;3.16,-.84,;3.16,-2.38,;4.49,-3.15,;5.83,-2.38,;4.49,-4.69,;4.49,-.07,;5.83,-.84,;7.16,-.07,;7.16,1.47,;8.49,2.24,;5.83,2.24,;4.49,1.47,;-2.65,-2.3,;-4.19,-2.3,;-4.67,-.84,;-6,-.07,;-6.48,1.4,;-8.02,1.4,;-8.49,-.07,;-7.25,-.97,)| Show InChI InChI=1S/C25H34N6O6S/c1-15(2)37-22(23-26-13-16(3)14-27-23)17(4)38(32,33)30-25-29-28-24(20-11-8-12-36-20)31(25)21-18(34-5)9-7-10-19(21)35-6/h7,9-10,13-15,17,20,22H,8,11-12H2,1-6H3,(H,29,30)/t17-,20+,22+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.780	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10150760 (2018) BindingDB Entry DOI: 10.7270/Q2MS3VVT
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM310301 (US10150760, Example 97.0 | US10150760, Example 98....) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,wD:18.19,33.35,(-7.42,2.38,;-6.09,1.61,;-4.76,2.38,;-4.76,3.92,;-3.42,4.69,;-2.09,3.92,;-2.09,2.38,;-.75,1.61,;.58,2.38,;-3.42,1.61,;-3.42,.07,;-2.18,-.84,;-.84,-.07,;.49,-.84,;-.28,-2.17,;1.26,-2.17,;1.82,-.07,;1.82,1.47,;3.16,-.84,;3.16,-2.38,;4.49,-3.15,;5.83,-2.38,;4.49,-4.69,;4.49,-.07,;5.83,-.84,;7.16,-.07,;7.16,1.47,;8.49,2.24,;5.83,2.24,;4.49,1.47,;-2.65,-2.3,;-4.19,-2.3,;-4.67,-.84,;-6,-.07,;-6.48,1.4,;-8.02,1.4,;-8.49,-.07,;-7.25,-.97,)| Show InChI InChI=1S/C25H34N6O6S/c1-15(2)37-22(23-26-13-16(3)14-27-23)17(4)38(32,33)30-25-29-28-24(20-11-8-12-36-20)31(25)21-18(34-5)9-7-10-19(21)35-6/h7,9-10,13-15,17,20,22H,8,11-12H2,1-6H3,(H,29,30)/t17-,20+,22+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10150760 (2018) BindingDB Entry DOI: 10.7270/Q2MS3VVT
					More data for this Ligand-Target Pair