BDBM311129 US10155751, Example 16
SMILES: C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)C1CC(C)(C)OC1(C)C)[C@H]1CNC(=O)C1
InChI Key: InChIKey=AEQMBFFFVYLEGX-DVLOMUPFSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SYK (aa 342-635) (Homo sapiens (Human)) | BDBM311129 (US10155751, Example 16) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D... | US Patent US10155751 (2018) BindingDB Entry DOI: 10.7270/Q2PK0J60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
FLT3 (aa 564-960) (Homo sapiens (Human)) | BDBM311129 (US10155751, Example 16) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Recombinant human FLT3 (amino acids 564-958, Molecular weight 48.6 kDa, Invitrogen #PR4666C) was expressed with an Histidine tag. The test compounds... | US Patent US10155751 (2018) BindingDB Entry DOI: 10.7270/Q2PK0J60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AURB (aa 1-341) (Homo sapiens (Human)) | BDBM311129 (US10155751, Example 16) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei... | US Patent US10155751 (2018) BindingDB Entry DOI: 10.7270/Q2PK0J60 | |||||||||||
More data for this Ligand-Target Pair |