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SMILES: C[C@@H](Nc1nn(C)c(=O)c2cccc(C)c12)[C@H](N(C)C)c1ccccc1

InChI Key: InChIKey=QTMVVXTXPFBUQU-BEFAXECRSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311491   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311491
PNG
(CHEM-US-00203 | US10155764, Example 70B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2cccc(C)c12)[C@H](N(C)C)c1ccccc1 |r|
Show InChI InChI=1S/C21H26N4O/c1-14-10-9-13-17-18(14)20(23-25(5)21(17)26)22-15(2)19(24(3)4)16-11-7-6-8-12-16/h6-13,15,19H,1-5H3,(H,22,23)/t15-,19+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.80E+3n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair