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SMILES: C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1cccc(NC(C)=O)c1

InChI Key: InChIKey=VGKMKHIBCILRAU-ORAYPTAESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311494   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311494
PNG
(CHEM-US-00206 | US10155764, Example 72)
Show SMILES C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](N(C)C)c1cccc(NC(C)=O)c1 |r|
Show InChI InChI=1S/C21H26N6O2/c1-13(19(26(3)4)15-8-6-9-16(12-15)24-14(2)28)23-20-18-17(10-7-11-22-18)21(29)27(5)25-20/h6-13,19H,1-5H3,(H,23,25)(H,24,28)/t13-,19+/m0/s1
PDB
MMDB

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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 99n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair