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SMILES: Cn1cc(NC(=O)c2cnn3ccc(NCC4CNC(=O)C4)nc23)c(n1)C(N)=O

InChI Key: InChIKey=KFYSPWAINCXMRB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311540   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM311540
PNG
(N-(3-carbamoyl-1-methyl- 1H-pyrazol-4-yl)-5-{[(5- ...)
Show SMILES Cn1cc(NC(=O)c2cnn3ccc(NCC4CNC(=O)C4)nc23)c(n1)C(N)=O
Show InChI InChI=1S/C17H19N9O3/c1-25-8-11(14(24-25)15(18)28)22-17(29)10-7-21-26-3-2-12(23-16(10)26)19-5-9-4-13(27)20-6-9/h2-3,7-9H,4-6H2,1H3,(H2,18,28)(H,19,23)(H,20,27)(H,22,29)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 270n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...

US Patent US10155765 (2018)


BindingDB Entry DOI: 10.7270/Q21V5H2J
More data for this
Ligand-Target Pair