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SMILES: Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(CC(O)c3cccc(c3)-n3cnnn3)C[C@@H]2CO1

InChI Key: InChIKey=DTGYAMGHQPSIOC-QREQTRJTSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 312616   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM312616 (US9604998, Example 22 | US9604998, Example 23) Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(CC(O)c3cccc(c3)-n3cnnn3)C[C@@H]2CO1 |r| Show InChI InChI=1S/C24H26FN7O2/c1-16-20(6-7-21(25)24(16)26-2)23-13-31-9-8-30(11-19(31)14-34-23)12-22(33)17-4-3-5-18(10-17)32-15-27-28-29-32/h3-7,10,15,19,22-23,33H,8-9,11-14H2,1H3/t19-,22?,23+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9604998 (2017) BindingDB Entry DOI: 10.7270/Q2XW4MWK
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM312616 (US9604998, Example 22 | US9604998, Example 23) Show SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(CC(O)c3cccc(c3)-n3cnnn3)C[C@@H]2CO1 |r| Show InChI InChI=1S/C24H26FN7O2/c1-16-20(6-7-21(25)24(16)26-2)23-13-31-9-8-30(11-19(31)14-34-23)12-22(33)17-4-3-5-18(10-17)32-15-27-28-29-32/h3-7,10,15,19,22-23,33H,8-9,11-14H2,1H3/t19-,22?,23+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9604998 (2017) BindingDB Entry DOI: 10.7270/Q2XW4MWK
					More data for this Ligand-Target Pair