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SMILES: Cc1ccc(Cn2nc(-c3nnc4c(NC(=O)C4(C)C)n3)c3ccc(C)nc23)c(F)c1

InChI Key: InChIKey=YSBACACNDAJZPO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312945   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM312945
PNG
(3-[1-(2-Fluoro-4-methylbenzyl)-6-methyl-1H-pyrazol...)
Show SMILES Cc1ccc(Cn2nc(-c3nnc4c(NC(=O)C4(C)C)n3)c3ccc(C)nc23)c(F)c1
Show InChI InChI=1S/C22H20FN7O/c1-11-5-7-13(15(23)9-11)10-30-20-14(8-6-12(2)24-20)16(29-30)18-25-19-17(27-28-18)22(3,4)21(31)26-19/h5-9H,10H2,1-4H3,(H,25,26,28,31)
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US Patent
n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...

US Patent US9605008 (2017)


BindingDB Entry DOI: 10.7270/Q2DZ0BC2
More data for this
Ligand-Target Pair