BDBM313601 2-(1,1-difluoroethyl)-N- (3-(6-ethoxy-5- (tetrahydro-2H-pyran-4- yl)pyridazin-3-yl)-4- methylphenyl) isonicotinamide::US10167279, Example 225

SMILES: CCOc1nnc(cc1C1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(F)F)ccc1C

InChI Key: InChIKey=PSZRMDFZYQWUMK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313601   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM313601 (2-(1,1-difluoroethyl)-N- (3-(6-ethoxy-5- (tetrahyd...) Show SMILES CCOc1nnc(cc1C1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(F)F)ccc1C Show InChI InChI=1S/C26H28F2N4O3/c1-4-35-25-21(17-8-11-34-12-9-17)15-22(31-32-25)20-14-19(6-5-16(20)2)30-24(33)18-7-10-29-23(13-18)26(3,27)28/h5-7,10,13-15,17H,4,8-9,11-12H2,1-3H3,(H,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...				US Patent US10167279 (2019) BindingDB Entry DOI: 10.7270/Q2W0981V
					More data for this Ligand-Target Pair