BDBM313754 US10167282, Compound TBAP-05

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1ccnc(O)c1

InChI Key: InChIKey=VUNDVBODCIFXGP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
B-Raf (V600E) (Homo sapiens (Human))	BDBM313754 (US10167282, Compound TBAP-05) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1ccnc(O)c1 Show InChI InChI=1S/C26H23FN8O4/c1-26(2,3)19-12-20(35(34-19)14-6-8-28-21(36)10-14)32-25(38)31-17-5-4-15(11-16(17)27)39-18-7-9-29-24-23(18)30-13-22(37)33-24/h4-13H,1-3H3,(H,28,36)(H,29,33,37)(H2,31,32,38)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) US Patent					Assay Description Mutant BRAF WM266.4 Cells.				US Patent US10167282 (2019) BindingDB Entry DOI: 10.7270/Q2GQ70V2
					More data for this Ligand-Target Pair
B-Raf (V600E) (Homo sapiens (Human))	BDBM313754 (US10167282, Compound TBAP-05) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1ccnc(O)c1 Show InChI InChI=1S/C26H23FN8O4/c1-26(2,3)19-12-20(35(34-19)14-6-8-28-21(36)10-14)32-25(38)31-17-5-4-15(11-16(17)27)39-18-7-9-29-24-23(18)30-13-22(37)33-24/h4-13H,1-3H3,(H,28,36)(H,29,33,37)(H2,31,32,38)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) US Patent					Assay Description V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...				US Patent US10167282 (2019) BindingDB Entry DOI: 10.7270/Q2GQ70V2
					More data for this Ligand-Target Pair