Found 3 hits for monomerid = 313770 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM313770
(US10167285, Comp 2)Show SMILES COc1cc(Cl)c(SC2Nc3cnc(F)nc3N2CCCC#C)c(OC)c1OC Show InChI InChI=1S/C19H20ClFN4O3S/c1-5-6-7-8-25-17-12(10-22-18(21)24-17)23-19(25)29-16-11(20)9-13(26-2)14(27-3)15(16)28-4/h1,9-10,19,23H,6-8H2,2-4H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
Memorial Sloan Kettering Cancer Center
US Patent
| Assay Description The biochemical assay tests competitive binding of compounds to recombinant Hsp90α protein and also Hsp90 found in cell specific complexes, and ... |
US Patent US10167285 (2019)
BindingDB Entry DOI: 10.7270/Q2BZ684R |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM313770
(US10167285, Comp 2)Show SMILES COc1cc(Cl)c(SC2Nc3cnc(F)nc3N2CCCC#C)c(OC)c1OC Show InChI InChI=1S/C19H20ClFN4O3S/c1-5-6-7-8-25-17-12(10-22-18(21)24-17)23-19(25)29-16-11(20)9-13(26-2)14(27-3)15(16)28-4/h1,9-10,19,23H,6-8H2,2-4H3 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Memorial Sloan Kettering Cancer Center
US Patent
| |
US Patent US10167285 (2019)
BindingDB Entry DOI: 10.7270/Q2BZ684R |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM313770
(US10167285, Comp 2)Show SMILES COc1cc(Cl)c(SC2Nc3cnc(F)nc3N2CCCC#C)c(OC)c1OC Show InChI InChI=1S/C19H20ClFN4O3S/c1-5-6-7-8-25-17-12(10-22-18(21)24-17)23-19(25)29-16-11(20)9-13(26-2)14(27-3)15(16)28-4/h1,9-10,19,23H,6-8H2,2-4H3 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Memorial Sloan Kettering Cancer Center
US Patent
| |
US Patent US10167285 (2019)
BindingDB Entry DOI: 10.7270/Q2BZ684R |
More data for this Ligand-Target Pair | |