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SMILES: NC(=O)[C@H]1CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC(=O)[C@H](CC2CC2)NC(=O)\C=C\C(=O)N1

InChI Key: InChIKey=USGADUBEYCQBGA-UTLNILCXSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 314093   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-degrading enzyme


(Homo sapiens (Human))		BDBM314093
PNG
(US9610322, 5a (cis olefin))
Show SMILES NC(=O)[C@H]1CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC(=O)[C@H](CC2CC2)NC(=O)\C=C\C(=O)N1 |r,t:53|
Show InChI InChI=1S/C43H54N4O7/c44-42(53)34-14-8-3-9-15-37(48)35(25-30-18-20-32(21-19-30)41(52)31-12-6-2-7-13-31)47-43(54)33(24-28-10-4-1-5-11-28)27-38(49)36(26-29-16-17-29)46-40(51)23-22-39(50)45-34/h2,6-7,12-13,18-23,28-29,33-36H,1,3-5,8-11,14-17,24-27H2,(H2,44,53)(H,45,50)(H,46,51)(H,47,54)/b23-22+/t33-,34-,35?,36+/m1/s1
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KEGG

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US Patent
n/an/a>2.00E+4n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...

US Patent US9610322 (2017)


BindingDB Entry DOI: 10.7270/Q29Z970C
More data for this
Ligand-Target Pair