BDBM315163 (3R/S)-3-[3-({(2R/S)-2-Cyclopentyl-2-[4-(5-ethylpyridin-3-yl)phenyl]acetyl}amino)-2-methylphenyl]pentanoic acid::US10172814, Example 105
SMILES: CCC(CC(O)=O)c1cccc(NC(=O)C(C2CCCC2)c2ccc(cc2)-c2cncc(CC)c2)c1C
InChI Key: InChIKey=YCZXGDRTZAULOW-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E synthase/G/H synthase 2 (Homo sapiens (Human)) | BDBM315163 ((3R/S)-3-[3-({(2R/S)-2-Cyclopentyl-2-[4-(5-ethylpy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12.9 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ... | US Patent US10172814 (2019) BindingDB Entry DOI: 10.7270/Q20K2BNW | |||||||||||
More data for this Ligand-Target Pair |