BDBM31535 pyrazolo[4,3-h]quinazoline-3-carboxamide, 18

SMILES: Cn1nc(C(=O)NCCO)c2CCc3cnc(Nc4ccccc4)nc3-c12

InChI Key: InChIKey=NXZVLIWBXMLTSL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 31535   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM31535 (pyrazolo[4,3-h]quinazoline-3-carboxamide, 18) Show SMILES Cn1nc(C(=O)NCCO)c2CCc3cnc(Nc4ccccc4)nc3-c12 Show InChI InChI=1S/C19H20N6O2/c1-25-17-14(16(24-25)18(27)20-9-10-26)8-7-12-11-21-19(23-15(12)17)22-13-5-3-2-4-6-13/h2-6,11,26H,7-10H2,1H3,(H,20,27)(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	364	n/a	n/a	n/a	n/a	n/a	25
Nerviano Medical Sciences Srl					Assay Description The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...				J Med Chem 52: 5152-63 (2009) Article DOI: 10.1021/jm9006559 BindingDB Entry DOI: 10.7270/Q2JH3JJP
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human))	BDBM31535 (pyrazolo[4,3-h]quinazoline-3-carboxamide, 18) Show SMILES Cn1nc(C(=O)NCCO)c2CCc3cnc(Nc4ccccc4)nc3-c12 Show InChI InChI=1S/C19H20N6O2/c1-25-17-14(16(24-25)18(27)20-9-10-26)8-7-12-11-21-19(23-15(12)17)22-13-5-3-2-4-6-13/h2-6,11,26H,7-10H2,1H3,(H,20,27)(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	7.4	23
Nerviano Medical Sciences Srl					Assay Description The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...				J Med Chem 52: 5152-63 (2009) Article DOI: 10.1021/jm9006559 BindingDB Entry DOI: 10.7270/Q2JH3JJP
					More data for this Ligand-Target Pair