BDBM315760 US10172859, Example 181::US9732094, Example 181::[2-Chloro-4-fluoro- 5-(7-morpholin-4-yl- quinazolin-4-yl)- phenyl]-(4-methyl- thiazol-2-yl)- methanol1H NMR (500 MHz, DMSO-d6) ppm = 9.10 (s,1H), 7.73 (dd, J = 10.5, 8.6, 2H), 7.57-7.51 (m,2H), 7.22-7.18 (m, 2H), 6.97 (s, 1H), 6.26 (s,1H), 3.80-3.74 (m, 4H), 3.49-3.41 (m, 4H),2.30 (d, J = 1.0, 3H)

SMILES: Cc1csc(n1)C(O)c1cc(c(F)cc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1

InChI Key: InChIKey=ZNMXTDAANBXETP-UHFFFAOYSA-N

Data: 2 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 315760   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM315760 (US10172859, Example 181 | US11065253, Example 181 ...) Show SMILES Cc1csc(n1)C(O)c1cc(c(F)cc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1 Show InChI InChI=1S/C23H20ClFN4O2S/c1-13-11-32-23(28-13)22(30)16-9-17(19(25)10-18(16)24)21-15-3-2-14(8-20(15)26-12-27-21)29-4-6-31-7-5-29/h2-3,8-12,22,30H,4-7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...				US Patent US9732094 (2017) BindingDB Entry DOI: 10.7270/Q2J67K1S
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM315760 (US10172859, Example 181 | US11065253, Example 181 ...) Show SMILES Cc1csc(n1)C(O)c1cc(c(F)cc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1 Show InChI InChI=1S/C23H20ClFN4O2S/c1-13-11-32-23(28-13)22(30)16-9-17(19(25)10-18(16)24)21-15-3-2-14(8-20(15)26-12-27-21)29-4-6-31-7-5-29/h2-3,8-12,22,30H,4-7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...				US Patent US10172859 (2019) BindingDB Entry DOI: 10.7270/Q23B626S
					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit (Homo sapiens (Human))	BDBM315760 (US10172859, Example 181 | US11065253, Example 181 ...) Show SMILES Cc1csc(n1)C(O)c1cc(c(F)cc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1 Show InChI InChI=1S/C23H20ClFN4O2S/c1-13-11-32-23(28-13)22(30)16-9-17(19(25)10-18(16)24)21-15-3-2-14(8-20(15)26-12-27-21)29-4-6-31-7-5-29/h2-3,8-12,22,30H,4-7H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit (Homo sapiens (Human))	BDBM315760 (US10172859, Example 181 | US11065253, Example 181 ...) Show SMILES Cc1csc(n1)C(O)c1cc(c(F)cc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1 Show InChI InChI=1S/C23H20ClFN4O2S/c1-13-11-32-23(28-13)22(30)16-9-17(19(25)10-18(16)24)21-15-3-2-14(8-20(15)26-12-27-21)29-4-6-31-7-5-29/h2-3,8-12,22,30H,4-7H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...				US Patent US10172859 (2019) BindingDB Entry DOI: 10.7270/Q23B626S
					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit (Homo sapiens (Human))	BDBM315760 (US10172859, Example 181 | US11065253, Example 181 ...) Show SMILES Cc1csc(n1)C(O)c1cc(c(F)cc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1 Show InChI InChI=1S/C23H20ClFN4O2S/c1-13-11-32-23(28-13)22(30)16-9-17(19(25)10-18(16)24)21-15-3-2-14(8-20(15)26-12-27-21)29-4-6-31-7-5-29/h2-3,8-12,22,30H,4-7H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Patent GmbH US Patent					Assay Description The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...				US Patent US9732094 (2017) BindingDB Entry DOI: 10.7270/Q2J67K1S
					More data for this Ligand-Target Pair