BDBM31595 substituted pyrazole, 12

SMILES: CCn1ncc(c1-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1

InChI Key: InChIKey=UFBIOSDYTOETCT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31595   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat))	BDBM31595 (substituted pyrazole, 12) Show SMILES CCn1ncc(c1-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1 Show InChI InChI=1S/C26H22N4O/c1-2-30-26(24(17-28-30)19-13-15-27-16-14-19)21-8-11-23(12-9-21)31-18-22-10-7-20-5-3-4-6-25(20)29-22/h3-17H,2,18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.76	n/a	n/a	n/a	n/a	7.5	23
Pfizer					Assay Description PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...				J Med Chem 52: 5188-96 (2009) Article DOI: 10.1021/jm900521k BindingDB Entry DOI: 10.7270/Q290223B
					More data for this Ligand-Target Pair