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SMILES: COc1ccc(CNc2nc3n(ncc3c(=O)[nH]2)C2CCCC2)cc1

InChI Key: InChIKey=KMGGUFXXPCBUKB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317077   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Homo sapiens (Human))		BDBM317077
PNG
(US9617269, Compound WYQ-28)
Show SMILES COc1ccc(CNc2nc3n(ncc3c(=O)[nH]2)C2CCCC2)cc1
Show InChI InChI=1S/C18H21N5O2/c1-25-14-8-6-12(7-9-14)10-19-18-21-16-15(17(24)22-18)11-20-23(16)13-4-2-3-5-13/h6-9,11,13H,2-5,10H2,1H3,(H2,19,21,22,24)
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US Patent
n/an/a 20n/an/an/an/an/an/a



Sun Yat-Sen University; University of North Carolina at Chapel Hill

US Patent


Assay Description
Inhibition activities of all the N-substituted pyrazolo [3,4-d] pyrimidine ketone compounds according to the present invention to the phosphodiestera...

US Patent US9617269 (2017)


BindingDB Entry DOI: 10.7270/Q2RX9F4B
More data for this
Ligand-Target Pair