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SMILES: Cc1c(nc2ccc(CCc3nc(N4CCCC4)n(C)n3)nn12)C(F)(F)F

InChI Key: InChIKey=VGWQQXTVMNQBRU-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317148   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM317148
PNG
(3-Methyl-6-(2-(1-methyl-5-(pyrrolidin-1-yl)-1H-1,2...)
Show SMILES Cc1c(nc2ccc(CCc3nc(N4CCCC4)n(C)n3)nn12)C(F)(F)F
Show InChI InChI=1S/C17H20F3N7/c1-11-15(17(18,19)20)22-14-8-6-12(23-27(11)14)5-7-13-21-16(25(2)24-13)26-9-3-4-10-26/h6,8H,3-5,7,9-10H2,1-2H3
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MMDB

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US Patent
n/an/a 19n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...

US Patent US9617271 (2017)


BindingDB Entry DOI: 10.7270/Q2N58PFC
More data for this
Ligand-Target Pair