BDBM317211 N,3-Dimethyl-6-((1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)ethynyl)-2-(trifluoromethyl)imidazo[1,2-b]pyridazine-8-carboxamide::US9617271, 69

SMILES: CNC(=O)c1cc(nn2c(C)c(nc12)C(F)(F)F)C#Cc1nc(nn1C)N1CCCC1

InChI Key: InChIKey=XWTQXVNKAROBOP-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317211   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM317211 (N,3-Dimethyl-6-((1-methyl-3-(pyrrolidin-1-yl)-1H-1...) Show SMILES CNC(=O)c1cc(nn2c(C)c(nc12)C(F)(F)F)C#Cc1nc(nn1C)N1CCCC1 Show InChI InChI=1S/C19H19F3N8O/c1-11-15(19(20,21)22)25-16-13(17(31)23-2)10-12(26-30(11)16)6-7-14-24-18(27-28(14)3)29-8-4-5-9-29/h10H,4-5,8-9H2,1-3H3,(H,23,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...				US Patent US9617271 (2017) BindingDB Entry DOI: 10.7270/Q2N58PFC
					More data for this Ligand-Target Pair