null

SMILES: OC(CC1c2ccccc2-c2cnnn12)C1CCC(F)(F)CC1

InChI Key: InChIKey=LQHHDYXPADTYTB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 317222   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM317222 (US9617272, Compound 68 | US9981973, Compound 68) Show SMILES OC(CC1c2ccccc2-c2cnnn12)C1CCC(F)(F)CC1 Show InChI InChI=1S/C17H19F2N3O/c18-17(19)7-5-11(6-8-17)16(23)9-14-12-3-1-2-4-13(12)15-10-20-21-22(14)15/h1-4,10-11,14,16,23H,5-9H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
NewLink Genetics Corporation US Patent					Assay Description The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...				US Patent US9617272 (2017) BindingDB Entry DOI: 10.7270/Q2HD7XQN
					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM317222 (US9617272, Compound 68 | US9981973, Compound 68) Show SMILES OC(CC1c2ccccc2-c2cnnn12)C1CCC(F)(F)CC1 Show InChI InChI=1S/C17H19F2N3O/c18-17(19)7-5-11(6-8-17)16(23)9-14-12-3-1-2-4-13(12)15-10-20-21-22(14)15/h1-4,10-11,14,16,23H,5-9H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50 values for each compound were determined by testing the activity of TDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2K35X00
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM317222 (US9617272, Compound 68 | US9981973, Compound 68) Show SMILES OC(CC1c2ccccc2-c2cnnn12)C1CCC(F)(F)CC1 Show InChI InChI=1S/C17H19F2N3O/c18-17(19)7-5-11(6-8-17)16(23)9-14-12-3-1-2-4-13(12)15-10-20-21-22(14)15/h1-4,10-11,14,16,23H,5-9H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2K35X00
					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM317222 (US9617272, Compound 68 | US9981973, Compound 68) Show SMILES OC(CC1c2ccccc2-c2cnnn12)C1CCC(F)(F)CC1 Show InChI InChI=1S/C17H19F2N3O/c18-17(19)7-5-11(6-8-17)16(23)9-14-12-3-1-2-4-13(12)15-10-20-21-22(14)15/h1-4,10-11,14,16,23H,5-9H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
NewLink Genetics Corporation US Patent					Assay Description The IC50 values for each compound were determined by testing the activity of TDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...				US Patent US9617272 (2017) BindingDB Entry DOI: 10.7270/Q2HD7XQN
					More data for this Ligand-Target Pair