BDBM317463 4-(4-(cyclopentyloxy)-5-(6- methoxypyridin-3-yl)-7H- pyrrolo[2,3-d]pyrimidin-2- ylamino)-3-methoxy-N- methylbenzamide::US9623028, Compound 55
SMILES: CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc(OC)nc2)c(OC)c1
InChI Key: InChIKey=AVTFVXIWVBJUJO-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM317463 (4-(4-(cyclopentyloxy)-5-(6- methoxypyridin-3-yl)-7...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Signal Pharmaceuticals, LLC US Patent | Assay Description The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet... | US Patent US9623028 (2017) BindingDB Entry DOI: 10.7270/Q2VQ34R8 | |||||||||||
More data for this Ligand-Target Pair |