null

SMILES: CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cn1)C#N

InChI Key: InChIKey=RWPDOIAHAORHAK-DEOSSOPVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 318002   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM318002 (US10399976, Compound 155 | US10807980, Compound 15...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cn1)C#N |r| Show InChI InChI=1S/C26H24F3N5O/c1-16(2)24-23-20(15-34(24)14-17-3-6-21(7-4-17)26(27,28)29)9-19(12-32-23)25(35)33-13-22-8-5-18(10-30)11-31-22/h3-9,11-12,16,24H,13-15H2,1-2H3,(H,33,35)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, LLC US Patent					Assay Description Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...				US Patent US10807980 (2020)
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM318002 (US10399976, Compound 155 | US10807980, Compound 15...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cn1)C#N |r| Show InChI InChI=1S/C26H24F3N5O/c1-16(2)24-23-20(15-34(24)14-17-3-6-21(7-4-17)26(27,28)29)9-19(12-32-23)25(35)33-13-22-8-5-18(10-30)11-31-22/h3-9,11-12,16,24H,13-15H2,1-2H3,(H,33,35)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, LLC US Patent					Assay Description Compounds of the present invention were tested for ability to bind to ROR gamma in a cell-free competition assay with commercially available radio-li...				US Patent US10399976 (2019) BindingDB Entry DOI: 10.7270/Q2F76FXT
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM318002 (US10399976, Compound 155 | US10807980, Compound 15...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cn1)C#N |r| Show InChI InChI=1S/C26H24F3N5O/c1-16(2)24-23-20(15-34(24)14-17-3-6-21(7-4-17)26(27,28)29)9-19(12-32-23)25(35)33-13-22-8-5-18(10-30)11-31-22/h3-9,11-12,16,24H,13-15H2,1-2H3,(H,33,35)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Compounds of the present invention were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-li...				US Patent US9624217 (2017) BindingDB Entry DOI: 10.7270/Q29P33RJ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM318002 (US10399976, Compound 155 | US10807980, Compound 15...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cn1)C#N |r| Show InChI InChI=1S/C26H24F3N5O/c1-16(2)24-23-20(15-34(24)14-17-3-6-21(7-4-17)26(27,28)29)9-19(12-32-23)25(35)33-13-22-8-5-18(10-30)11-31-22/h3-9,11-12,16,24H,13-15H2,1-2H3,(H,33,35)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, LLC US Patent					Assay Description Compounds of the present invention were tested for RORγ inverse agonist activity in a cell-based, transcriptional activity assay. Secreted Nanol...				US Patent US10807980 (2020)
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM318002 (US10399976, Compound 155 | US10807980, Compound 15...) Show SMILES CC(C)[C@@H]1N(Cc2ccc(cc2)C(F)(F)F)Cc2cc(cnc12)C(=O)NCc1ccc(cn1)C#N |r| Show InChI InChI=1S/C26H24F3N5O/c1-16(2)24-23-20(15-34(24)14-17-3-6-21(7-4-17)26(27,28)29)9-19(12-32-23)25(35)33-13-22-8-5-18(10-30)11-31-22/h3-9,11-12,16,24H,13-15H2,1-2H3,(H,33,35)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, LLC US Patent					Assay Description Compounds of the present invention were tested for ROR gamma inverse agonist activity in a cell-based, transcriptional activity assay. Secreted Nanol...				US Patent US10399976 (2019) BindingDB Entry DOI: 10.7270/Q2F76FXT
					More data for this Ligand-Target Pair