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SMILES: CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2C#N)CC1

InChI Key: InChIKey=FXPQKIUFVMHDMQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318039   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM318039 (2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2C#N)CC1 Show InChI InChI=1S/C19H23N7O/c1-24-7-3-5-15-17(24)22-19(23-18(15)27)26-10-8-25(9-11-26)13-16-14(12-20)4-2-6-21-16/h2,4,6H,3,5,7-11,13H2,1H3,(H,22,23,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM318039 (2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2C#N)CC1 Show InChI InChI=1S/C19H23N7O/c1-24-7-3-5-15-17(24)22-19(23-18(15)27)26-10-8-25(9-11-26)13-16-14(12-20)4-2-6-21-16/h2,4,6H,3,5,7-11,13H2,1H3,(H,22,23,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318039 (2-[[4-(8-Methyl-4-oxo-3,5,6,7-tetrahydropyrido[2,3...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2C#N)CC1 Show InChI InChI=1S/C19H23N7O/c1-24-7-3-5-15-17(24)22-19(23-18(15)27)26-10-8-25(9-11-26)13-16-14(12-20)4-2-6-21-16/h2,4,6H,3,5,7-11,13H2,1H3,(H,22,23,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.41	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair