BDBM31850 2,4-Bisanilinopyrimidine, 12

SMILES: COc1ccc(Nc2ncc(F)c(Nc3ccc(OC)cc3)n2)cc1

InChI Key: InChIKey=DKMPKZLVZFPNDI-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 31850   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM31850 (2,4-Bisanilinopyrimidine, 12) Show SMILES COc1ccc(Nc2ncc(F)c(Nc3ccc(OC)cc3)n2)cc1 Show InChI InChI=1S/C18H17FN4O2/c1-24-14-7-3-12(4-8-14)21-17-16(19)11-20-18(23-17)22-13-5-9-15(25-2)10-6-13/h3-11H,1-2H3,(H2,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.43E+3	n/a	n/a	n/a	n/a
Amarit Bioscience, Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay				Bioorg Med Chem Lett 25: 2117-21 (2015) Article DOI: 10.1016/j.bmcl.2015.03.075 BindingDB Entry DOI: 10.7270/Q2R49SFK
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM31850 (2,4-Bisanilinopyrimidine, 12) Show SMILES COc1ccc(Nc2ncc(F)c(Nc3ccc(OC)cc3)n2)cc1 Show InChI InChI=1S/C18H17FN4O2/c1-24-14-7-3-12(4-8-14)21-17-16(19)11-20-18(23-17)22-13-5-9-15(25-2)10-6-13/h3-11H,1-2H3,(H2,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Genentech					Assay Description Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...				J Med Chem 52: 3300-7 (2009) Article DOI: 10.1021/jm9000314 BindingDB Entry DOI: 10.7270/Q2M90706
					More data for this Ligand-Target Pair