BDBM318875 N-(2-fluoro-3-(2-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide::US10172868, Compound C048::US10653701, Compound C048::US11304957, Compound C048

SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cn1

InChI Key: InChIKey=UKMFJDYDNMGZMP-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 318875   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM318875 (N-(2-fluoro-3-(2-((6-(4-methylpiperazin-1-yl)pyrid...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cn1 Show InChI InChI=1S/C27H26FN7O/c1-3-24(36)32-22-9-5-7-20(25(22)28)21-8-4-6-18-16-30-27(33-26(18)21)31-19-10-11-23(29-17-19)35-14-12-34(2)13-15-35/h3-11,16-17H,1,12-15H2,2H3,(H,32,36)(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...				US Patent US10172868 (2019) BindingDB Entry DOI: 10.7270/Q25141BX
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318875 (N-(2-fluoro-3-(2-((6-(4-methylpiperazin-1-yl)pyrid...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cn1 Show InChI InChI=1S/C27H26FN7O/c1-3-24(36)32-22-9-5-7-20(25(22)28)21-8-4-6-18-16-30-27(33-26(18)21)31-19-10-11-23(29-17-19)35-14-12-34(2)13-15-35/h3-11,16-17H,1,12-15H2,2H3,(H,32,36)(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...				US Patent US10172868 (2019) BindingDB Entry DOI: 10.7270/Q25141BX
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318875 (N-(2-fluoro-3-(2-((6-(4-methylpiperazin-1-yl)pyrid...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cn1 Show InChI InChI=1S/C27H26FN7O/c1-3-24(36)32-22-9-5-7-20(25(22)28)21-8-4-6-18-16-30-27(33-26(18)21)31-19-10-11-23(29-17-19)35-14-12-34(2)13-15-35/h3-11,16-17H,1,12-15H2,2H3,(H,32,36)(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318875 (N-(2-fluoro-3-(2-((6-(4-methylpiperazin-1-yl)pyrid...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cn1 Show InChI InChI=1S/C27H26FN7O/c1-3-24(36)32-22-9-5-7-20(25(22)28)21-8-4-6-18-16-30-27(33-26(18)21)31-19-10-11-23(29-17-19)35-14-12-34(2)13-15-35/h3-11,16-17H,1,12-15H2,2H3,(H,32,36)(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description (i) Peptide/Kinase Mixtures for measurement of EGFR (ErbB1):The 2×EGFR (ErbB1)/Tyr 04 mixture is prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM...				US Patent US10653701 (2020)
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM318875 (N-(2-fluoro-3-(2-((6-(4-methylpiperazin-1-yl)pyrid...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cn1 Show InChI InChI=1S/C27H26FN7O/c1-3-24(36)32-22-9-5-7-20(25(22)28)21-8-4-6-18-16-30-27(33-26(18)21)31-19-10-11-23(29-17-19)35-14-12-34(2)13-15-35/h3-11,16-17H,1,12-15H2,2H3,(H,32,36)(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM318875 (N-(2-fluoro-3-(2-((6-(4-methylpiperazin-1-yl)pyrid...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4F)c3n2)cn1 Show InChI InChI=1S/C27H26FN7O/c1-3-24(36)32-22-9-5-7-20(25(22)28)21-8-4-6-18-16-30-27(33-26(18)21)31-19-10-11-23(29-17-19)35-14-12-34(2)13-15-35/h3-11,16-17H,1,12-15H2,2H3,(H,32,36)(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description (i) Peptide/Kinase Mixtures for measurement of EGFR (ErbB1):The 2×EGFR (ErbB1)/Tyr 04 mixture is prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM...				US Patent US10653701 (2020)
					More data for this Ligand-Target Pair