BDBM318969 US10173991, Example 10::benzyl N-{4-[2- ({[(cyclopropyl- carbamoyl) methyl] carbamoyl}(2- methoxyethane- sulfonyl)methyl)- 6-fluoro-1,3- benzothiazol-5- yl]phenyl} carbamate

SMILES: OCCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(c(F)cc2s1)-c1ccc(NC(=O)OCc2ccccc2)cc1

InChI Key: InChIKey=SZGQPWLLLLJICQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 318969   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM318969 (US10173991, Example 10 | benzyl N-{4-[2- ({[(cyclo...) Show SMILES OCCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(c(F)cc2s1)-c1ccc(NC(=O)OCc2ccccc2)cc1 Show InChI InChI=1S/C31H31FN4O7S2/c32-24-16-26-25(15-23(24)20-7-9-22(10-8-20)35-31(40)43-18-19-5-2-1-3-6-19)36-30(44-26)28(45(41,42)14-4-13-37)29(39)33-17-27(38)34-21-11-12-21/h1-3,5-10,15-16,21,28,37H,4,11-14,17-18H2,(H,33,39)(H,34,38)(H,35,40)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...				US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8
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