BDBM319469 (3-cyanophenyl) methyl N-{4-[2- ({[(cyclopropyl- carbamoyl) methyl] carbamoyl}(3,3,3- trifluoropropane- sulfonyl)methyl)- 5-fluoro-1,3- benzothiazol- 6-yl]phenyl} carbamate::US10173991, Example 522

SMILES: Fc1cc2nc(sc2cc1-c1ccc(NC(=O)OCc2cccc(c2)[N+]#[C-])cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F

InChI Key: InChIKey=BKKRNBBVLVPNFE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319469   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM319469 ((3-cyanophenyl) methyl N-{4-[2- ({[(cyclopropyl- c...) Show SMILES Fc1cc2nc(sc2cc1-c1ccc(NC(=O)OCc2cccc(c2)[N+]#[C-])cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F Show InChI InChI=1S/C32H27F4N5O6S2/c1-37-22-4-2-3-18(13-22)17-47-31(44)40-21-7-5-19(6-8-21)23-14-26-25(15-24(23)33)41-30(48-26)28(49(45,46)12-11-32(34,35)36)29(43)38-16-27(42)39-20-9-10-20/h2-8,13-15,20,28H,9-12,16-17H2,(H,38,43)(H,39,42)(H,40,44)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...				US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8
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