BDBM319496 US10173991, Example 552::benzyl N-{5-[2- ({[(cyclopropyl- carbamoyl)methyl] carbamoyl} (methanesulfonyl) methyl)-5-fluoro- 1,3-benzothiazol- 6-yl]pyridin-2- yl}carbamate

SMILES: CS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(NC(=O)OCc2ccccc2)nc1

InChI Key: InChIKey=UCTXRIJOEMMAKQ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319496   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM319496 (US10173991, Example 552 | benzyl N-{5-[2- ({[(cycl...) Show SMILES CS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(NC(=O)OCc2ccccc2)nc1 Show InChI InChI=1S/C28H26FN5O6S2/c1-42(38,39)25(26(36)31-14-24(35)32-18-8-9-18)27-33-21-12-20(29)19(11-22(21)41-27)17-7-10-23(30-13-17)34-28(37)40-15-16-5-3-2-4-6-16/h2-7,10-13,18,25H,8-9,14-15H2,1H3,(H,31,36)(H,32,35)(H,30,34,37)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...				US Patent US10173991 (2019) BindingDB Entry DOI: 10.7270/Q2N018M8
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