BindingDB logo
myBDB logout

BDBM319517 N-{4-[2- ({[(cyclopropyl- carbamoyl)methyl] carbamoyl}(2- methoxyethane- sulfonyl)methyl)- 5-fluoro-1,3- benzothiazol-6- yl]phenyl}-3- phenyl- propanamide::US10173991, Example 577

SMILES: COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(NC(=O)CCc2ccccc2)cc1

InChI Key: InChIKey=MNACOROAYLXWJN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319517   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))		BDBM319517
PNG
(N-{4-[2- ({[(cyclopropyl- carbamoyl)methyl] carbam...)
Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(NC(=O)CCc2ccccc2)cc1
Show InChI InChI=1S/C32H33FN4O6S2/c1-43-15-16-45(41,42)30(31(40)34-19-29(39)36-23-12-13-23)32-37-26-18-25(33)24(17-27(26)44-32)21-8-10-22(11-9-21)35-28(38)14-7-20-5-3-2-4-6-20/h2-6,8-11,17-18,23,30H,7,12-16,19H2,1H3,(H,34,40)(H,35,38)(H,36,39)
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...

US Patent US10173991 (2019)


BindingDB Entry DOI: 10.7270/Q2N018M8
More data for this
Ligand-Target Pair