BDBM319658 2-{1-[2-(4-fluorophenyl)ethyl]-1H-imidazol-4-yl}-4- [5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl]pyridine::US10174003, Example 77

SMILES: FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2ccc(I)cc2)cn1

InChI Key: InChIKey=MCRWUHRVWUZEBE-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 319658   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM319658 (2-{1-[2-(4-fluorophenyl)ethyl]-1H-imidazol-4-yl}-4...) Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2ccc(I)cc2)cn1 Show InChI InChI=1S/C19H14F3IN6/c20-19(21,22)18-17(26-28-27-18)13-5-7-24-15(9-13)16-10-29(11-25-16)8-6-12-1-3-14(23)4-2-12/h1-5,7,9-11H,6,8H2,(H,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM319658 (2-{1-[2-(4-fluorophenyl)ethyl]-1H-imidazol-4-yl}-4...) Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2ccc(I)cc2)cn1 Show InChI InChI=1S/C19H14F3IN6/c20-19(21,22)18-17(26-28-27-18)13-5-7-24-15(9-13)16-10-29(11-25-16)8-6-12-1-3-14(23)4-2-12/h1-5,7,9-11H,6,8H2,(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD3 was determined in 384-well plate format under the following reaction conditions: 1 nM ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM319658 (2-{1-[2-(4-fluorophenyl)ethyl]-1H-imidazol-4-yl}-4...) Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2ccc(I)cc2)cn1 Show InChI InChI=1S/C19H14F3IN6/c20-19(21,22)18-17(26-28-27-18)13-5-7-24-15(9-13)16-10-29(11-25-16)8-6-12-1-3-14(23)4-2-12/h1-5,7,9-11H,6,8H2,(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM319658 (2-{1-[2-(4-fluorophenyl)ethyl]-1H-imidazol-4-yl}-4...) Show SMILES FC(F)(F)c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2ccc(I)cc2)cn1 Show InChI InChI=1S/C19H14F3IN6/c20-19(21,22)18-17(26-28-27-18)13-5-7-24-15(9-13)16-10-29(11-25-16)8-6-12-1-3-14(23)4-2-12/h1-5,7,9-11H,6,8H2,(H,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair