null
SMILES: CCOC(=O)Nc1cc-2c(OCc3cc(OC[C@@](C)(N)CC(C)C)ccc-23)cn1
InChI Key: InChIKey=MWHCLYMKQNOMIN-QFIPXVFZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AP2-associated protein kinase 1 (Homo sapiens (Human)) | BDBM321107 ((S)-ethyl (8-((2-amino-2,4-dimethylpentyl)oxy)-6H-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
KU Leuven Curated by ChEMBL | Assay Description Inhibition of thrombin-recognition site-fused GST-tagged human AAK1 expressed in bacterial expression system using 5-FAM-Aha-KEEQSQITSQVTGQIGWR-NH2 a... | J Med Chem 62: 5810-5831 (2019) Article DOI: 10.1021/acs.jmedchem.9b00136 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AP2-associated protein kinase 1 (Homo sapiens (Human)) | BDBM321107 ((S)-ethyl (8-((2-amino-2,4-dimethylpentyl)oxy)-6H-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra... | US Patent US10174044 (2019) BindingDB Entry DOI: 10.7270/Q2222WVN | |||||||||||
More data for this Ligand-Target Pair |