BDBM322154 2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin-2-yl)phenoxy)-N-(piperidin-4-yl)acetamide hydrochloride::US10183931, Example 28::US10696660, Example 28::US9815820, ex. 28

SMILES: Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1

InChI Key: InChIKey=MPLCIPBYGVWSAJ-UHFFFAOYSA-N

Data: 6 KI  10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 322154   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...				US Patent US10696660 (2020)
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...				US Patent US10183931 (2019) BindingDB Entry DOI: 10.7270/Q27M0B04
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...				US Patent US9815820 (2017) BindingDB Entry DOI: 10.7270/Q2KS6TP0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...				US Patent US9815820 (2017) BindingDB Entry DOI: 10.7270/Q2KS6TP0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...				US Patent US10696660 (2020)
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...				US Patent US10183931 (2019) BindingDB Entry DOI: 10.7270/Q27M0B04
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...				US Patent US10696660 (2020)
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.96E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...				US Patent US10696660 (2020)
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...				US Patent US10696660 (2020)
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.96E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...				US Patent US9815820 (2017) BindingDB Entry DOI: 10.7270/Q2KS6TP0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...				US Patent US9815820 (2017) BindingDB Entry DOI: 10.7270/Q2KS6TP0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.96E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...				US Patent US10183931 (2019) BindingDB Entry DOI: 10.7270/Q27M0B04
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...				US Patent US10183931 (2019) BindingDB Entry DOI: 10.7270/Q27M0B04
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...				US Patent US10696660 (2020)
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...				US Patent US10183931 (2019) BindingDB Entry DOI: 10.7270/Q27M0B04
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM322154 (2-(3-(4-((1H-indazol-5-yl)amino)-5-methylpyrimidin...) Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1cccc(OCC(=O)NC2CCNCC2)c1 Show InChI InChI=1S/C25H27N7O2/c1-16-13-27-25(31-24(16)30-20-5-6-22-18(11-20)14-28-32-22)17-3-2-4-21(12-17)34-15-23(33)29-19-7-9-26-10-8-19/h2-6,11-14,19,26H,7-10,15H2,1H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...				US Patent US10183931 (2019) BindingDB Entry DOI: 10.7270/Q27M0B04
					More data for this Ligand-Target Pair