BDBM322342 (R)-7-fluoro-6-methyl-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2]octan]-3'-yl)benzo[b]thiophene-2-carboxamide::US10183938, Compound (R)-106
SMILES: Cc1ccc2cc(sc2c1F)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
InChI Key: InChIKey=UCMQJTUETDQVSF-QGZVFWFLSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human)) | BDBM322342 ((R)-7-fluoro-6-methyl-N-(1'-azaspiro[cyclopropane-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM322342 ((R)-7-fluoro-6-methyl-N-(1'-azaspiro[cyclopropane-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description [3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair |