BDBM322538 5-[[3-(4-phenyl-1H-imidazol-2-yl)-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one::US10183939, Example 16

SMILES: O=C1CCc2c(Oc3ccc4OCC(=Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1

InChI Key: InChIKey=KHJXEABVQFMOBM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322538   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-RAF (Y340D Y341D) (Homo sapiens (Human))	BDBM322538 (5-[[3-(4-phenyl-1H-imidazol-2-yl)-2H-chromen-6-yl]...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(=Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1 |c:13| Show InChI InChI=1S/C26H20N4O3/c31-24-9-7-20-23(10-11-27-26(20)30-24)33-19-6-8-22-17(13-19)12-18(15-32-22)25-28-14-21(29-25)16-4-2-1-3-5-16/h1-6,8,10-14H,7,9,15H2,(H,28,29)(H,27,30,31)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent									US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair
B-Raf (V600E) (Homo sapiens (Human))	BDBM322538 (5-[[3-(4-phenyl-1H-imidazol-2-yl)-2H-chromen-6-yl]...) Show SMILES O=C1CCc2c(Oc3ccc4OCC(=Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1 |c:13| Show InChI InChI=1S/C26H20N4O3/c31-24-9-7-20-23(10-11-27-26(20)30-24)33-19-6-8-22-17(13-19)12-18(15-32-22)25-28-14-21(29-25)16-4-2-1-3-5-16/h1-6,8,10-14H,7,9,15H2,(H,28,29)(H,27,30,31)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent					Assay Description To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...				US Patent US10183939 (2019) BindingDB Entry DOI: 10.7270/Q2QN68WX
					More data for this Ligand-Target Pair