BDBM323053 4-[({(1R,2R or 1S,2S)-2-[2-Fluoro-4-(3- methyl-1H-pyrazol-5-yl)benzoyl] cyclohexyl}carbonyl)amino]-1-methyl-1H- pyrazole-3-carboxamide::US10183947, Example 36::US10508119, Example 36

SMILES: Cc1cc([nH]n1)-c1ccc(C(=O)C2CCCCC2C(=O)Nc2cn(C)nc2C(N)=O)c(F)c1

InChI Key:

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 323053   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM323053 (4-[({(1R,2R or 1S,2S)-2-[2-Fluoro-4-(3- methyl-1H-...) Show SMILES Cc1cc([nH]n1)-c1ccc(C(=O)C2CCCCC2C(=O)Nc2cn(C)nc2C(N)=O)c(F)c1 |w:17.19,12.12| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
ASTRAZENECA AB US Patent					Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...				US Patent US10508119 (2019) BindingDB Entry DOI: 10.7270/Q2FB55BJ
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM323053 (4-[({(1R,2R or 1S,2S)-2-[2-Fluoro-4-(3- methyl-1H-...) Show SMILES Cc1cc([nH]n1)-c1ccc(C(=O)C2CCCCC2C(=O)Nc2cn(C)nc2C(N)=O)c(F)c1 |w:17.19,12.12| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
ASTRAZENECA AB US Patent					Assay Description Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...				US Patent US10183947 (2019) BindingDB Entry DOI: 10.7270/Q22Z17M7
					More data for this Ligand-Target Pair