BDBM32429 Benzo[c][2,7]naphthyridine, 23

SMILES: COc1cc2c(cc1OCC1CCN(C)CC1)ncc1c(N)nc(cc21)-c1ccncc1

InChI Key: InChIKey=JHRBNIITDPSBMU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 32429   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) (Homo sapiens (Human))	BDBM32429 (Benzo[c][2,7]naphthyridine, 23) Show SMILES COc1cc2c(cc1OCC1CCN(C)CC1)ncc1c(N)nc(cc21)-c1ccncc1 Show InChI InChI=1S/C25H27N5O2/c1-30-9-5-16(6-10-30)15-32-24-13-22-19(12-23(24)31-2)18-11-21(17-3-7-27-8-4-17)29-25(26)20(18)14-28-22/h3-4,7-8,11-14,16H,5-6,9-10,15H2,1-2H3,(H2,26,29)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.92E+3	n/a	n/a	n/a	n/a	7.4	23
Wyeth Research					Assay Description A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...				Bioorg Med Chem Lett 19: 5225-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.007 BindingDB Entry DOI: 10.7270/Q2XK8CXJ
					More data for this Ligand-Target Pair