BDBM324326 N-(8-(2-((1H-pyrazol-4- yl)amino)pyrimidin-4- yl)-2-(oxetan-3-yl)- 2,3,4,5-tetrahydro-1H- benzo[c]azepin-5-yl)-5- (tert-butyl)-1,3,4- oxadiazole-2- carboxamide::US10189829, Compound 92::US10227341, Compound 92::US10961237, Compound 92
SMILES: CC(C)(C)c1nnc(o1)C(=O)NC1CCN(Cc2cc(ccc12)-c1ccnc(Nc2cn[nH]c2)n1)C1COC1
InChI Key:
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM324326 (N-(8-(2-((1H-pyrazol-4- yl)amino)pyrimidin-4- yl)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
BIOGEN MA INC. US Patent | Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a... | US Patent US10189829 (2019) BindingDB Entry DOI: 10.7270/Q2V69MP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM324326 (N-(8-(2-((1H-pyrazol-4- yl)amino)pyrimidin-4- yl)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
BIOGEN MA INC. US Patent | Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a... | US Patent US10961237 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM324326 (N-(8-(2-((1H-pyrazol-4- yl)amino)pyrimidin-4- yl)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 505 | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience | Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a... | J Med Chem 51: 1730-9 (2008) BindingDB Entry DOI: 10.7270/Q25M681D | |||||||||||
More data for this Ligand-Target Pair |