BDBM32440 Benzo[c][2,7]naphthyridine, 32

SMILES: COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(Nc2ccccc2)c1

InChI Key: InChIKey=XPBLRWQJIYHWGF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 32440   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) (Homo sapiens (Human))	BDBM32440 (Benzo[c][2,7]naphthyridine, 32) Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(Nc2ccccc2)c1 Show InChI InChI=1S/C25H21N5O2/c1-31-23-10-19-18-9-21(30-25(26)20(18)14-28-22(19)11-24(23)32-2)15-8-17(13-27-12-15)29-16-6-4-3-5-7-16/h3-14,29H,1-2H3,(H2,26,30)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	283	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...				Bioorg Med Chem Lett 19: 5225-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.007 BindingDB Entry DOI: 10.7270/Q2XK8CXJ
					More data for this Ligand-Target Pair