BDBM32445 Benzo[c][2,7]naphthyridine, 37

SMILES: COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(Nc2cccc(CO)c2)c1

InChI Key: InChIKey=FFWNZIAZKHNJHQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 32445   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) (Homo sapiens (Human))	BDBM32445 (Benzo[c][2,7]naphthyridine, 37) Show SMILES COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(Nc2cccc(CO)c2)c1 Show InChI InChI=1S/C26H23N5O3/c1-33-24-9-20-19-8-22(31-26(27)21(19)13-29-23(20)10-25(24)34-2)16-7-18(12-28-11-16)30-17-5-3-4-15(6-17)14-32/h3-13,30,32H,14H2,1-2H3,(H2,27,31)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest differenti...				Bioorg Med Chem Lett 19: 5225-8 (2009) Article DOI: 10.1016/j.bmcl.2009.07.007 BindingDB Entry DOI: 10.7270/Q2XK8CXJ
					More data for this Ligand-Target Pair