null

SMILES: Brc1ccc(o1)C(=O)Nc1cccc(Nc2ccccc2)c1N1CCN(CC=C)CC1

InChI Key: InChIKey=KXOWPDXQFCZQJI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 32474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM32474 (piperazine amide, 4u) Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(Nc2ccccc2)c1N1CCN(CC=C)CC1 Show InChI InChI=1S/C24H25BrN4O2/c1-2-13-28-14-16-29(17-15-28)23-19(26-18-7-4-3-5-8-18)9-6-10-20(23)27-24(30)21-11-12-22(25)31-21/h2-12,26H,1,13-17H2,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...				Bioorg Med Chem Lett 19: 3344-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.086 BindingDB Entry DOI: 10.7270/Q2ST7N67
					More data for this Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] (Homo sapiens (Human))	BDBM32474 (piperazine amide, 4u) Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(Nc2ccccc2)c1N1CCN(CC=C)CC1 Show InChI InChI=1S/C24H25BrN4O2/c1-2-13-28-14-16-29(17-15-28)23-19(26-18-7-4-3-5-8-18)9-6-10-20(23)27-24(30)21-11-12-22(25)31-21/h2-12,26H,1,13-17H2,(H,27,30)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.0	22
The Scripps Research Institute					Assay Description Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...				Bioorg Med Chem Lett 19: 3344-7 (2009) Article DOI: 10.1016/j.bmcl.2009.03.086 BindingDB Entry DOI: 10.7270/Q2ST7N67
					More data for this Ligand-Target Pair