BDBM325171 9-(4-(3-hydroxyazetidine-1-carbonyl)benzyl)-2-(2-::US10189841, Compound I-377::US10399980, Compound I-377

SMILES: CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)C(=O)N3CC(O)C3)c2n1

InChI Key: InChIKey=MGQBHVDXXAYHRH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 325171   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ubiquitin carboxyl-terminal hydrolase 1 (Homo sapiens (Human))	BDBM325171 (9-(4-(3-hydroxyazetidine-1-carbonyl)benzyl)-2-(2- ...) Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)C(=O)N3CC(O)C3)c2n1 Show InChI InChI=1S/C25H25N5O3/c1-15(2)19-5-3-4-6-20(19)22-26-11-21-23(28-22)30(25(33)27-21)12-16-7-9-17(10-8-16)24(32)29-13-18(31)14-29/h3-11,15,18,31H,12-14H2,1-2H3,(H,27,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. US Patent					Assay Description The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...				US Patent US10399980 (2019) BindingDB Entry DOI: 10.7270/Q23J3GCX
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1 (Homo sapiens (Human))	BDBM325171 (9-(4-(3-hydroxyazetidine-1-carbonyl)benzyl)-2-(2- ...) Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)C(=O)N3CC(O)C3)c2n1 Show InChI InChI=1S/C25H25N5O3/c1-15(2)19-5-3-4-6-20(19)22-26-11-21-23(28-22)30(25(33)27-21)12-16-7-9-17(10-8-16)24(32)29-13-18(31)14-29/h3-11,15,18,31H,12-14H2,1-2H3,(H,27,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.00200	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc. US Patent					Assay Description The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...				US Patent US10189841 (2019) BindingDB Entry DOI: 10.7270/Q22R3TRR
					More data for this Ligand-Target Pair