BDBM32551 arylsulfonylpiperazine, 23

SMILES: Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccccn1

InChI Key: InChIKey=JEDMJGUYLWTGKO-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 32551   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM32551 (arylsulfonylpiperazine, 23) Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccccn1 Show InChI InChI=1S/C16H19N3O2S/c1-14-5-7-15(8-6-14)22(20,21)19-12-10-18(11-13-19)16-4-2-3-9-17-16/h2-9H,10-13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc.					Assay Description Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...				Bioorg Med Chem Lett 18: 3513-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.025 BindingDB Entry DOI: 10.7270/Q2J964Q1
					More data for this Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) (Homo sapiens (Human))	BDBM32551 (arylsulfonylpiperazine, 23) Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccccn1 Show InChI InChI=1S/C16H19N3O2S/c1-14-5-7-15(8-6-14)22(20,21)19-12-10-18(11-13-19)16-4-2-3-9-17-16/h2-9H,10-13H2,1H3	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	>1.00E+3	n/a	n/a	7.2	22
Amgen Inc.					Assay Description Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...				Bioorg Med Chem Lett 18: 3513-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.025 BindingDB Entry DOI: 10.7270/Q2J964Q1
					More data for this Ligand-Target Pair				3D Structure (docked)