BDBM326149 US10273223, Compound D-47::US9637472, Compound D-47

SMILES: Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CC2)C(=O)CN)c(=O)[nH]1

InChI Key: InChIKey=BRXRFPLZPKKMRZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 326149   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM326149 (US10273223, Compound D-47 | US9637472, Compound D-...) Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CC2)C(=O)CN)c(=O)[nH]1 |t:27| Show InChI InChI=1S/C28H34N6O3/c1-17-11-18(2)32-28(37)23(17)15-30-27(36)22-12-20(19-7-9-33(10-8-19)26(35)14-29)13-25-24(22)16-31-34(25)21-5-3-4-6-21/h7,11-13,16,21H,3-6,8-10,14-15,29H2,1-2H3,(H,30,36)(H,32,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
IRBM/Merck					Assay Description eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....				J Med Chem 51: 2350-3 (2008) BindingDB Entry DOI: 10.7270/Q28P62V9
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Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM326149 (US10273223, Compound D-47 | US9637472, Compound D-...) Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CC2)C(=O)CN)c(=O)[nH]1 |t:27| Show InChI InChI=1S/C28H34N6O3/c1-17-11-18(2)32-28(37)23(17)15-30-27(36)22-12-20(19-7-9-33(10-8-19)26(35)14-29)13-25-24(22)16-31-34(25)21-5-3-4-6-21/h7,11-13,16,21H,3-6,8-10,14-15,29H2,1-2H3,(H,30,36)(H,32,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...				US Patent US9637472 (2017) BindingDB Entry DOI: 10.7270/Q2X0693B
					More data for this Ligand-Target Pair